What is a chronically toxic dose of eugenol?

How much cloves is too much? I see on the MSDS that the rat LD50 is 1930 mg/kg, which no reasonable person would consume in one day. But I wonder about the effects of consuming a large amount every day. Can anyone find some data on the lowest reported oral dose of eugenol (in mg per kg) that showed long-term toxicity in a human? Or, conversely, the highest reported dose that was shown to be nontoxic over the long-term?

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GarethT101 year ago

WHO rda is 2.5mg/kg

kelseymh8 years ago

The primary research appears to be on cytotoxicity (tissue damage) from zinc-oxide-eugenol compounds used as periodontic sealers (e.g., after root canals). I didn't find any articles on the first two pages which dealt with whole-body toxicity.
I suspect it would be difficult to absorb enough cloves to cause issues. Clove oil would be a likely candidate for overdosage of eugenol. In general the doses that cause damage even in the long term seem to be far beyond what any one would take in during a day...