Questions about MAOI interactions.

My friend and I have been working on a project, and this project has required a lot of research. I've been able to figure out most of what I need to know and now there is only one major issue left. That has to do with monoamine oxidase inhibitors.

I've done some research and found a few helpful websites here and here. At the first website I found that "If you stop taking an MAOI, you should not start taking another antidepressant for two or three weeks." So, does that mean MAO inhibitors stay in your system for two to three weeks? Also, does that mean that all of the "Foods to Avoid" from the second website should be avoided for the full duration of the two to three weeks?

Any help would be greatly appreciated.

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lemonie8 years ago
What's the project? L
Gjdj3 (author)  lemonie8 years ago
I could PM you the details if you want.
lemonie Gjdj38 years ago
I'm interested. L
A lot of stuff does stay in your system for a while before being fully metabolized. Sounds like MAOIs are one of them.
keithjk18 years ago
I had a fience, she was on Zoloft and was taking Natural Homopathic and Herbal supplements to treat her depression. The combination caused "issues". Since I do not know about the caution of mixing prescription 2 MAOs, I do have experience of the supplementing with MAOs. I would suggest during the switch from one to the other, become like a leech to your Doctor. This way if any changes start to effect you, they will be the first to see it. It is always harder to see the forest threw the tree. This also can tell the Doctor when your clean of the old prescription, in your moods/actions. Everyperson is different what takes one 2 weeks, another it might take 4. Also, other drugs like anti histimines for allergies might effect all this as well. Another this My fience would take weekends off on the meds. The reason was after a while the drugs would as she once said/described... "I could be stuck on a train track, in a broken down car, with a train heading at me, and I would have a grin on my face and not realizing it was about to hit me". With weekends off, she her body was able to detox a bit from saturation of the meds in her system. In short: Have your doctor closely monitor you. Most of the stuff on the web is either general info (the rule) or personal experiences (exceptions). Just don't get caught making "The Exceptions the Rule". Because each person reacts differently at different phases.
Gjdj3 (author)  keithjk18 years ago
Thanks for your help. This information was what I was looking for.
Goodhart8 years ago
First off, I agree with keithjk1.

Secondly, to directly answer your questions: At the first website I found that "If you stop taking an MAOI, you should not start taking another antidepressant for two or three weeks." So, does that mean MAO inhibitors stay in your system for two to three weeks? Also, does that mean that all of the "Foods to Avoid" from the second website should be avoided for the full duration of the two to three weeks?

Simple answers: yes (maybe longer) and (definitely) yes. Although each person may react differently to meds and suppliments, erring on the side of caution would be best in this case.
Gjdj3 (author)  Goodhart8 years ago
That's what I was thinking, I just wanted to be sure. Thank you!