Picture of (2000) F-250 Door Lock actuator repair
Let's skip all the mumble-jumbo and jump right to the work. Lets go!

WARNING: If your truck is under warranty do NOT do this, as it will VOID your warranty.

you will need a good day or two to do this job. as it can be a hassle.

You'll need to begin by opening the doors up. There are 2 screws holding each door panel on. (9/32 socket will remove them)

The first screw is located under the "control panel" (the part with your window controls/lock controls), you remove this part by lifting the smallest end straight up. once the clip releases, pull up and out to remove the other side.

The red reflector can be removed with a flat head screw driver.
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Step 1: Once you have gotten the screws out

Picture of Once you have gotten the screws out
Next you want to remove the black column above the door panel. This will pull straight out

Step 2: Removing the door panel

To remove the door panel, Simply Lift straight up. once the clips release, you can pull it away from the door itself. You can now set this aside

Step 3: Getting the actuator out

Picture of Getting the actuator out
Let me stop and apologize now. as i didnt have enough hands to take the pictures of everything as I went along. Hopefully I will be able to put it in typing, and you'll be able to understand it and follw the steps - 

with the door panel removed, you'll notice a plastic like sheet stuck to the door with stickem's, peel this off, and set it aside sticky side up. From there you will want to remove the outter door handle, 2 nuts hold this unit in (I belive they're 12 mm). the top one can be done with a ratchet, but the other one will require you to reach inside the door with a wrench.