My glasses were bothering me and cutting into my nose, sometimes even making me bleed.
Step 1: Applying Sugru
I covered the parts causing me pain with Sugru.
Step 2: Adjusting
I tried them on and shaped the Sugru to the best fit possible. Then it have to cure for 24 hours. Using the glasses while the Sugru cured made my skin itch, so it's not recommended. After the curing they fit and didn't cause any discomfort anymore. YAY!