It all about placement, no cheesy mood lighting here...
Step 1: Why bother?
A few different lights all of which can be aquired for less than ÃÂ£15 are all it takes, you might notice that Don't use my ceiling lights, they're halogen so I hate their inefficiency and general crappiness.
My normal room light is as down below. Making your room different isn't hard or pointless, being able to change the lighting in your room quickly is nice and allows for variation from the norm.