Having trouble impressing the other persuasion with some furious fretwork? Not no more! NOTE: This applies to guitar only. If I get enough good feedback I'll make one for singing and drums on RB.
Step 1: Getting to Know Your Guitar
It sounds dumb, but you have to be able to know the guitar with your eyes closed. If you use the Rock Band Stratocaster, there are little braille bumpies that identify the green, yellow, and orange buttons. On the Guitar Hero SG and Les Paul, There is a line on the yellow button. So just make sure you can make your way over to these without thinking about it too much.