Step 1: Required Tools
Sawzall (or Grinder or Cutter or Saw)
Dremmel (or Drill)
Sander (Optional for clean look)
Step 2: Required Materials
2) Acrylic Sheet
Thicker or impact resistant Acrylic would be a good recommendation.
Sintra (a PVC variant used for outdoor signs) would also be a good recommendation. It is light, durable / indestructable and cheep.
Step 3: Cut Wheel Wells
Step 4: Bend Acrylic Body
The trick with bending Acrylic is to only heat up the areas that you need at just the right tempature. If you heat up the Acrylic too much it will carmalize, bubbles will appear and it will turn cloudy. Heat it up until it starts to bend and then stop.
I used the edge of my counter as a brace / mold.