Instructables
Picture of Sugru Soldering Iron Custom Grip
I have been soldering a bunch of circuits lately and my hand has been getting fatigued. I thought that a bit of Sugru would help out. 
 
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Step 1: RTFM - Cut open package...

Picture of RTFM - Cut open package...
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Get your stuff together and cut open package. Then knead the Sugru. 

Step 2: Shape the Sugru and wait...

Picture of Shape the Sugru and wait...
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I added a bit of Sugru to the 3 main contact points with my hand.

Step 3: Enjoy soldering bliss!

Picture of Enjoy soldering bliss!
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Now the iron feels great. I hope that you found this useful!