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The Process of Calibration

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Calibration of instrument is critical for reporting test results accurately, so that the outcome stays within the validated performance levels.
 
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Step 1: Understanding the Concept of Instrument Calibration

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Calibration involves configuration of an instrument to generate accurate results in the industry accepted range for test samples. The exercise seeks to eliminate or minimize the adverse factors affecting streamlined performance of an instrument of calibration.

Calibration procedure is instrument specific. That means there are separate procedures for temperature calibration, pressure, flow, pipette, dimension calibration etc. The calibration process seeks to make the instrument test against a number of calibrators, whose exact values are known. The outcomes are analyzed for gauging the sanctity of measurement techniques and the integrity of sample test results. The process fine tunes the instrument to make it immune to unfavorable conditions and produce unwavering results against unknown test products.

The emphasis is on establishing the correlation at critical points within the instrument’s functional scope. Using large number of calibrators may be desirable, however the feasibility of the same cannot be justified in terms of labor, time and capital involved. The product’s intended performance level and calibration related efforts have to be balanced. Optimum performance can be guaranteed when compliance to manufacturer’s performance specifications is accomplished by eliminating innate instrument errors at vulnerable intermediate points.

Step 2: Importance of Calibration

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The results of calibration would indicate the points within the operating range of instrument. Where deviations are observed can significantly hamper the accuracy of outcome. Equipment calibration will bring about improvements in the situation. Testing equipment against calibrators with known values will serve to set right all errors between given points to attain ideal condition. Minor errors, if any would be reconciled to stay within the accuracy specification published by manufacturer.
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