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We used a combination of Hot Shot Bed Bug and flea killer (liquid in gallon with sprayer) and Ortho Home Defense (also the liquid) and that has worked for us along with cleaning and laundering EVERYTHING!! The worst part for me is that I am highly allergic to the nasty things!! My skin is very scarred but slowly improving. Even worse is the psychological damage it causes. Have not slept more than 4-5 hours a night for over a year. Hope this is helpful and good luck to all who are dealing with these nasty critters!!