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What is a chronically toxic dose of eugenol? Answered

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How much cloves is too much? I see on the MSDS that the rat LD50 is 1930 mg/kg, which no reasonable person would consume in one day. But I wonder about the effects of consuming a large amount every day. Can anyone find some data on the lowest reported oral dose of eugenol (in mg per kg) that showed long-term toxicity in a human? Or, conversely, the highest reported dose that was shown to be nontoxic over the long-term?

3 Replies

GarethT10 (author)2016-07-05
kelseymh (author)2009-02-07


The primary research appears to be on cytotoxicity (tissue damage) from zinc-oxide-eugenol compounds used as periodontic sealers (e.g., after root canals). I didn't find any articles on the first two pages which dealt with whole-body toxicity.

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killerjackalope (author)2009-02-07

I suspect it would be difficult to absorb enough cloves to cause issues. Clove oil would be a likely candidate for overdosage of eugenol. In general the doses that cause damage even in the long term seem to be far beyond what any one would take in during a day...

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