Treating Your Cat With Imidcloprid Flea Medication Such As "Advantage"





Introduction: Treating Your Cat With Imidcloprid Flea Medication Such As "Advantage"

I love my kitties, but I hate giving them medication, either orally or topically, because afterwards they always hate me, at least for little while (dogs, meanwhile, are usually much easier to treat because they are usually less wary). But I also hate parasites, and so I regularly treat my cats with some sort of flea medication. I have now developed a technique to minimize the stress on my cats and to at least make them hate me, well, less than they used to after a dosing. This Instructable will lay out how I do that.

There are several Instructables already on how to treat flea problems in your home, and none of these should be dismissed. Dusting with diatomaceous earth is always good and always safe, for example. But when you are finally done with "natural" treatments which may or may not work completely, and your kitties are still scratching, it may be time for imidacloprid. Note that scratching alone is not the only symptom of flea bites: cats will also suddenly lick themselves in a spot where they have just been bitten (as opposed to the regular lengthy "grooming" licks which are much more methodical and casual). If you notice your cat suddenly and briefly lick itself on any specific spot on its body, this may be a sign of a flea bite (flea bites cause pain, cats react to pain by licking the site of injury, therefore sudden licking is sometimes a sign of pain from a flea bite).

Imidacloprid is the main (though not only) ingredient in the topical flea ointment "Advantage" both for cats and for dogs. Advantage is expensive as flea medications go, but it is also highly effective (note that there is no difference in the ingredients between the cat version and the dog version— its all the same stuff, just in different size packaging). The good news is that it can sometimes be bought in bulk online at a greatly reduced price. The bad news is that if you get it this way, you have to do more of the application work yourself, including measuring actual dosages. The good news is that this is not very difficult and certainly should not deter you from bulk-purchasing it... If you can find it in bulk.

You will need the following things in order to get the most out of this Instructable:

- Advantage flea medication. If bought in bulk, this will usually include the following:
* a small empty amber glass vial
* a single large tube of Advantage imidacloprid medication suspended in a clear oil
* a small blunt syringe for measuring dosages

(This medication in bulk is occasionally but inconsistently available through The last seller I bought it from no longer carries it; the seller I bought it from before that also no longer carries it. When it was available, however, I was able to purchase a very large dose for only $23 which has lasted me for many months with two cats.)

[Warning: although any imidacloprid-based topical oil-based medication is likely suitable for this exercise, do not, I repeat do NOT substitute any Hartz-related flea medication for Advantage. A number of pets have apparently died as a direct result of the use of and subsequent allergic reactions to Hartz flea products (read the reviews for ample evidence of this tragedy) and the fact that it is still available for purchase anywhere in United States is a travesty worthy of multiple lawsuits. Do not buy Hartz-anything unless you are looking for an excruciating way to kill your pet.]

You should also obtain:
- A fine-tooth metal flea comb such as this one
- Some catnip, either dry or fresh depending on your cat's preferences, as bait — note that not all cats are responsive to catnip and some cats are only responsive to dried while others only respond to fresh; if your cat is not responsive to catnip consider trying Tatarian honeysuckle sawdust (about a third of house cats that don't respond to catnip will respond to this kind of sawdust as if it were catnip— Note that not all kinds of honeysuckle will work, only Tatarian seems to be effective as a catnip substitute). It is important to have either catnip or a catnip analog for this Instructable to work.
- Some form of cat treats, i.e., a special food the cat will never refuse, as further bait. Mine are especially fond of Temptations bite-size treats, and I can highly recommend them. If you can get your cat to respond to the sound of the shaking bag as a summons, then all the better. Mine come running whenever they hear the crinkle of the plastic bag. Without fail.
- A cat
- Fleas

[Photo credit: Wikimedia Commons]

Step 1: Prepping Your Cat and You

Acquaint the cat with a flea comb

A cat which has never been introduced to to a flea comb before will need to be exposed to one before being treated with imidacloprid. Flea combs are good for removing fleas, of course, but that is not why we will be using one here (more on that in a minute). Make sure your cat is comfortable being combed with a flea comb: let the cat smell it, rub his or her chin against it, and come to enjoy being brushed with it (maybe catch a few fleas while you are at it, even though all of these are about to die anyway). This may take some time, but it will be very important later. Even when I know my cats do not have fleas, I brush them with a flea comb simply to keep them accustomed to it. And they seem to like it quite a lot! Conveniently, my cats are both short-hairs which makes using the flea comb on them very easy.

Withhold treats and catnip

Cats like treats, and they also like catnip, but it is important not to expose the cat to either one ideally for several hours or even a day before attempting the following treatment. The excitement of the catnip and the treats must be relatively fresh for the cat, and if you just gave the cat these things earlier in the day, you will not get the necessary response later during this treatment routine. Treats, like catnip, should be special infrequent events in order for them to be their most powerful, and we need them at their most powerful for this regimen to succeed.

Prepare the dose of imidacloprid

This is one of the trickier parts of this treatment regimen. The adult dosage for most cats is .4 mL of the imidacloprid oil. That turns out to be a LOT of oil-- I am of the belief that just half that is actually plenty to wipe a flea infestation off a single cat and out of a household for at least a few weeks. The oil has a vaguely unpleasant smell but an extremely unpleasant bitter taste (though apparently not considered poisonous) for cats. Once a cat has tasted imidacloprid it will never forget the memory of the smell. This is why you must act with great stealth and under cover of catnip. When you are ready to begin treatment, and you have withheld treats/ catnip for hours, and your cat is already quite familiar with the flea comb and you have this comb nearby, you should proceed by opening the tube of imidacloprid and emptying its contents into the glass vial. Now suck .2-.4 mL into the syringe which should have come with your kit. Then turn the syringe upside down so that it is pointing upward and gently tap/ shake out any bubbles while avoiding spilling most of the medication out the tip. Working the plunger up and down a bit can help with this. We do not want to waste this precious, expensive stuff, but it is VERY IMPORTANT (for reasons you will soon understand) that in the end there be no bubbles in the syringe itself!!!

Once you have the syringe filled with the imidacloprid and evacuated any air, you should tuck the syringe under your arm in order to warm the fluid up to body temperature (imidacloprid oil may stain clothing, so I recommend doing this while wearing a tank top or something similar). The imidacloprid will not harm YOU in any way, so do not be afraid to get a drop or two of it on your skin while it is warming under your arm. Allow the syringe at least two or three min. to become properly warm. This is critical: Immediately wash your hands so that there is no trace of the medicine on your fingertips, and do not handle the syringe again until you have dispensed and resealed the bags of treats and catnip (see next step)-- if there is even a small amount left on your hands, you may contaminate the catnip and/ or treats, which will lose all appeal for your cats and this whole exercise will be for naught.

You have now prepped for the act of dosing your cat. If you have two or more (?) cats, you will have to figure out a way to do one and the other at about the same time: if one catches the smell of the medicine on another, it will become wary and suspicious and may then become evasive. I manage to do both my cats in the same deceptive moment, but it is not simple. The kitties are very clever. Yet they must be de-fleaed, for their sake as much as my own. Onward!

Step 2: Dose!

It is time for the treatment:

Summon your cat by shaking your bag of treats. Scatter several in front of the cat to give it lots of visual and olfactory targets. Next, shake a bit of catnip around the food as well to intoxicate the animal. The cat will conveniently place its head down towards the floor and be holding its shoulders and neck in the perfect position for treatment. Rub and gently scratch the cat between its shoulderblades as it indulges. Make it feel comfortable. Then, when least expected, remove the syringe from under your arm with your free hand and, without skipping a beat, deliver the squirt of medicine to the cat's neck/ shoulderblade area in a single, silent, warm, discrete, squirt (NOT TOO FAST!). Then rub it in as best you can with your fingertips, trying to work it down to the animal's skin. With any luck, and if you have followed these instructions carefully, the cat won't even notice what has happened for at least 5 minutes. Once you are done, go wash your hands again.

Alternate delivery method: As one of the tactile clues for the cat that something is "up" is the feel of the medicine against its skin/ hair, you may be better off (and are unlikely to be at all worse off) applying the medicine to your OWN fingertips while the cat has its head down in the catnip and treats and then using your fingers to work it into the fur between the shoulder blades. Consider this approach. The medicine will do nothing to you, and this may be better/ easier than the cat feeling the stuff oozing onto its skin causing a flight reaction before you get a chance to rub it in.

Now, why do you suppose I emphasizes how important it was for you to make sure there were no bubbles in the syringe? If there were, when you emptied the syringe onto the cat, the cat would hear a bubble or two go "pop" behind its head, and immediately turn and become suspicious. We need a silent syringe, silent and warm and well disguised. No bubbles. They are a giveaway. They are like the creaky floor or door hinge when you are trying to sneak across a room in the dark.

And yet we are not quite finished. Not long after the cat discovers that something has happened, it is likely to want to go and hide. This is natural. The cat will also attempt to lick itself clean of the medicine — if you applied it to the correct place on the neck, this should be difficult or impossible. But imidacloprid is a liquid, and does run a bit when it is first applied. This is why you must attempt to get it deep into the cat's fur and close to its skin with your fingertips immediately upon application. Once it hits the skin, the medicine will soon disperse over the cat's entire body in an even, microscopic layer of flea-death. That is the magic of the alcohol solvent in which the imidacloprid is suspended. If the medicine only gets on the fur, it will not spread so far or so effectively and you will end up having a lot of fleas around that you should not (you may need to retreat the cat if you still are noticing fleas after 48 hours or so).

The real magic is next: in the comb...

Step 3: Comb, and Recover

The flea comb is your best friend:

If everything has been done according to plan, and if your cat is at all social, it will soon come round to see you again and to cuddle up. This is your chance to make sure the imidacloprid gets where it needs to go: once your kitty is comfortably by you again, have the flea comb handy and begin gently combing the imidacloprid through the cat's fur around its neck. The cat should welcome and enjoy this experience, having no association between the comb and the medicine and only associating it with the pleasure of being combed. The cat may also perceive the comb as something like a giant tongue attempting to lick the sticky stuff off of its neck, which the cat will welcome (even though this is a mistaken belief, of course). Do not use the comb on any part of the cat other than its neck right now. We do not want to spread the imidacloprid to parts of the cats body which it will be able to lick later, we only want to work imidacloprid down through the fur and to the skin around the back of its neck and shoulder blades. Also note that we are not attempting to remove fleas here: imidacloprid will take care of that on its own within the next 12 hours. The fine teeth of the comb, however, are excellent for working the medicine down through the fur to the skin where it needs to be to kill the fleas. Also, the comb is perfect for dispersing the stickiness of the oil: your cat will hate, hate, hate the feeling of a wad of oil on its neck, but if you brush this oil down to its skin with the flea comb, the cat soon will barely notice the oil is there (other than the smell of it, which the cat will still hate, of course). This makes for a happier kitty. Getting dosed with imidacloprid is bad enough— if you can make it easier by combing it down to the skin, your cat will appreciate this (in a way).

Once your cat has enjoyed the pleasure of your combing it with the flea comb, your job is done: the cat has already forgiven you or never got the connection in the first place, and the fleas are going to die, die, die like the irritating demons they are. Wash out the flea comb with soap after you are done to remove the traces of imidacloprid which it has just picked up, and continue to give your kitty lots of loves, even if he/ she smells a little funny for a day or two. Remember that imidacloprid is non-toxic to mammals, so don't worry about getting it on you and don't let its presence keep you from petting your cat (but still, I wouldn't eat it).

Practice on all of this will make perfect: about once a month, depending on how much scratching and licking you see and on whether or not the flea comb, when used as originally intended, starts catching actual fleas.

I pass my wisdom on to you, and I wish you good luck!!!



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    14 Discussions

    Hello thanks for tips on how to give. May I check dosing as references say 0.4ml for cats up to 9 pounds and 0.8ml for those above. I was not sure if 4ml is correct?

    1 more answer

    Hi you can safely treat cats with the Advantage or Advantage 2 using the same measures. Bayer 's dose for a kitten is .23 ml . Thats about 2 1/2 lines on a standard 1 ml syringe. Their dose for a regular size cat under 10 lbs. is 0.4 ml . The 4 mark on a 1 cc syringe. and for large cats over 10 lbs they use 0.8 ml . which is the 8 mark on the 1 cc syringe. The dog and cat formula are the same only in the two Advantage products. If you buy the Extra Large Dog size each vial contains 4.0 ml . That would be 10 regular sized cat doses from each vial. |I must caution about Advantage MULTI . I only know for absolute certainty about regular Advantage and Advantage 2 .


    Question 7 weeks ago

    I had been searching to find if anyone with the knowledge has determined a bulk product like Adonis 75 WSP or similar, can be safely used, once diluted from 75.0% Imidacloprid to the <10% found in Advantage II topical.

    266 ml of 75.0% Imidacloprid cost $22.62 vs 4.8 ml (6pack) of 9.10% in Advantage II cost $51.00

    Of course there is that 25% of other ingredients in the Adonis product. Likely just dilution, but what is it diluted with, and is it toxic to a cat?

    1 more answer

    I do not know specifically what is in Adonis 75 WSP, but I can tell you this: after having done a few rounds with the original Advantage product and being annoyed by the cost, I decided to try making my own flea medication using the imidacloprid-based termiticide Dominion 2L and butyl alcohol purchased on eBay. I placed the Dominion product on a sheet of glass, warmed it under a light bulb until dry (can't use sunlight, as this destroys imidacloprid) then redissolved it using a few drops of the alcohol and applied it to my cat, with excellent results. Dominion is virtually nothing more than imidacloiprid dissolved in water— once that water is burned off and replaced with butyl alcohol, it becomes virtually the same product as Advantage— the other ingredients are of no toxic concern. I spent a LOT of time researching this to make sure! What my mixture lacks that Advantage has is a chemical to suppress the development of juvenile fleas. But as the adults get wiped out, this hasn't ended up mattering so much because the new juveniles that become adults and land on my cats also get killed by the imidacloprid. I had to research the patent on Dominion to figure this all out, and it wasn't easy to find. If you can track down the patent on Adonis, the relevant information should be there. Doninion I can speak for, however: it worked just fine, with no apparent side effects, even though it is designed for termites.

    I'm confused. Isn't the average dose 0.4 ml rather than 4 ml? 10x is a huge difference. Please clarify.

    1 more answer

    It should be 0.4ml, not 4. Am changing it now. Sorry about this— I know that there is a huge difference between the two. Somehow the . slipped through my fingers.

    I use the syringe and the largest dog package of 3 and kept my brown glass bottle. I wonder if you can get those little bottles from the pharmacy - they look like the ones that hold nitroglycerin pills. My instructions for the adult cat dose said to give 5 ml. I've been doing it for over a year now. Works great. My cats don't seem to mind getting dosed but I liked your instructable. They get a shower the day before gettind dosed so I think they know it's coming. lol

    7 replies

    You give your kitties a shower?? I never wash mine— they seem to do it themselves okay (!).

    In Florida the fleas are horrible all year round because of the sand and warm weather. Eventually their fur get's flea dirt and sand in it, because they love to roll around in the sand, and it feels awful to them and to me. They even start meowing at the shower when they know that they need one. They know it makes them feel so much better. My cats are really good in the shower even though they wail like I'm killing them. They stand still and are very cooperative. After they are finished and I dry them off, they act like they are a prince and princess preening and then when they are dry they chase each other around and carry on high. lol

    Yeah, wow! I think I would lose a lot of blood if I tried that! I have got my cats used to the idea of water though by thoroughly wetting my hands and then petting/wiping them down. I rinse the fur off my hands and then keep repeating. Works really well at helping them clean, and now they ask for it! Two had no interest until they watched the other one enjoying it. I can literally pour water on her (we think she is a little odd for a cat, and so do the other two!). Worth a try...

    I think part of the reason that they seem to accept it so well is that I have glass shower doors so they know there is no escape. I am in there with them and that seems to comfort them, and I talk to them in a soothing manner the entire time. They really do love it when I am massaging the Dawn dish soap (which is great for killing fleas too and safe for kittens as well) into their fur. They love getting their backs scratched too. Actually they more or less tell me when they want one. My male cat Hunter goes to the shower doors and starts meowing loudly like, "It's time to get clean, Mom". LOL

    I was wanting to know about the Dawn dish soap deal. how do you apply this to the cats? Do you mix dawn in with a certain amount of water? Does this kill the fleas and flea eggs, and lice? I was wanting to know as to how long this type of treatment works. I have 9 cats, that is a lot. 2 of them are very sensitive to flea meds and get real sick from them so I usually just pick the fleas out of them, basically popping their heads to kill them. I also brush out very well. My cats don't put up much of a fight as I believe they know what I am doing will benefit them greatly. They lay comfortable while I go to work on them. Any insight, help, or information will be much appreciated. I know you made this posting a while ago. Thank you, Derek

    Hello DerekB93, I am sorry that I didn't see your request for this information sooner. I find that if I put the cat into a plastic tote( like a one used to store stuff in that will fit into the shower) that has nice comfortably warm water in it and then use a cup rather than the shower hose to gently pour the warm water over him that he actually enjoys the bath. Also it helps to speak sweetly and soothingly to him as I do to make it more relaxing also helps. Once you have your pet's coat all wet then just squirt some Dawn dish soap into your hand as you would shampoo for your own head. You will know if you need a little bit here or there more in areas as you work it into a lather on your kitty. I also found that by sitting in the deeper warm water that it aided in drowning the fleas. After you have massaged the shampoo in (which my kitties loved getting massaged in the warm water) you will need to lift the kitty out of the tub and empty empty it. At this point you will have to use the shower hose to rinse off all the bubbles from his fur. I usually plan on needing 3 old bath towels per kitty since mine are could be Garfield's brother and sister in size. I find it is easier on my back to put them up on one of the towels that I have laid on the corner seat in the shower then use another one to start getting most of the water off of them. By that time they are antsy to get out of the shower and most of the water is off and they are no longer dripping so I open the shower door and let them out and use the last towel to finish rubbing them as dry as I can get them and just try to wrap it around them and settle them down on the floor until they feel dry enough to leave the towel. Sometimes if it's colder weather I will use a blow dryer to speed up the drying process by aiming it in their direction from about 6 ft away just to be sure that it isn't too hot for them. That's about it. You will see lots of dead fleas when you dump out the water from the tub and maybe even some on the towels if they were heavily infested. I would then apply their flea medicine after they were completely dry and brushed out. Hope this helps.

    I really don't measure anything I just squeeze enough out of the bottle to work up a good lather on their wet fur. Make sure that you use comfortably warm water and the room is warm as well. Kitties don't like to get chilled. Also have 3 bath towels available for each kitty. One to use immediately after the rinsing and then 2 more as their fur holds the water and I have found that number to work well. Dawn dish soap, the original type, is safe to use on animals. That is what they use to clean animals when they get covered in oil from oil spills. Just rinse them well and they will be fine. Try to leave the soap on them for a few minutes if they put up with it. The longer the soap is on them the more the fleas die. Use a flea comb and an old cup of soapy water to put the fur and any missed fleas in. Oh you will still comb some out after the bath but this will really finish the job. Again- the soapy water will make them drowned.

    Make sure that you vacuum frequently as well to lower the flea population. You can also put some water in some flat dishes (white preferably with a couple drops of dish soap in the water) on the floor and aim a light at them. The fleas with be attracted to the light and jump into the bowl of water and drowned because the soap breaks the surface tension of the water so they sink instead of being able to jump right out. It's amazing. Good luck.