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Seems to hold up pretty well, although I did add additional mounting points on all eight corners inside to make it a little stiffer. I haven't tested it with any fine detail cuts but so far I haven't noticed any significant difference between the MDF and HDPE
At the time I coated all the surfaces with a spray on sealant which in 6 months of use held up reasonably well (edge seepage was a bit of an issue probably more indicative of a non uniform coating). Since then however I've actually rebuilt the machine using HDPE sheets so I no longer have any concern with liquid.
Sienci Mill One Air/Oil Mist Coolant System View Instructable »