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For what it’s worth, here’s the story of my struggles with the USB-Blaster driver on windows 10 x64. Everything would compile just fine using Quartus Prime v16.1 lite, but when programming the board, I was getting errors about the JTAG chain or a (failed) message or even blue screen. Ultimately, I was able to resolve the issue by installing an older driver (2006) as per http://altera-guide.blogspot.com/. Yes, I had to disable driver signing and all that. However, I found that I had to uninstall the current driver (2012) first before the new one would be utilized. To do this, you need to go into device manager and uninstall the altera-usb blaster device, but be sure to check “Delete the driver software for this device” option. Good to go!